- The series will depict life many years after a nuclear war devastated humanity. One of the main characters, Lucy, portrayed by Ella Pernelle, will embark on her first journey outside the underground shelter on a rescue mission.
- Jonathan Nolan and Lisa Joy, known for "Westworld," worked on the adaptation of Fallout. The leading roles feature Ella Pournelle, Walton Goggins, and Kyle MacLachlan ("Twin Peaks").
- In the trailer, the series creators announced that all episodes will be available on April 11 on Prime Video, a day earlier than previously scheduled.
